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How Does Blood Ph Affect Oxygen Saturation

In contrast, an elevated (= alkaline or basic) blood plasma pH of 7.6 causes the O2-Hb saturation curve to shift about 15% to the left of normal. … As blood plasma pH decreases (= becomes more acidic), H+ ions increasingly bind to hemoglobin amino acids, which lessens hemoglobin’s affinity for O2

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